Which of the following is an inhibitor of citrate synthase?

Question

Quizplus · Accepted Answer

Succinyl-CoA is an intermediate in the citric acid cycle and can inhibit citrate synthase, the enzyme responsible for catalyzing the first step of the cycle. This is because the accumulation of succinyl-CoA indicates that there is sufficient energy production and there is no need for further citric acid cycle activity. Acetyl-CoA is a substrate for citrate synthase and would not inhibit it. [FADH₂] and ADP do not directly inhibit citrate synthase.

Which of the Following Is an Inhibitor of Citrate Synthase