Animal studies of the acute and chronic effects of antidepressants on serotonin have shown all of the following except
A) the autoreceptors are activated acutely, causing a decrease in synthesis and release of 5-HT.
B) the reuptake transporters remain blocked for the duration of the drug's action.
C) tolerance to the drug occurs at the autoreceptors chronically, resulting in increased 5-HT release.
D) setotonin occupancy of serotonin autoreceptors activates cell firing following chronic antidepressant treatment
Correct Answer:
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A)
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