Lack of cocaine self-administration by mutant mice expressing a cocaine-insensitive dopamine transporter tells us that

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Blockade of the dopamine transporter is crucial for the reinforcing effects of cocaine, as evidenced by mutant mice with a cocaine-insensitive dopamine transporter not self-administering cocaine. This suggests that cocaine's ability to block the dopamine transporter and increase dopamine levels in the brain is key to its reinforcing properties.

Lack of Cocaine Self-Administration by Mutant Mice Expressing a Cocaine-Insensitive