The excitotoxicity hypothesis states that
A) repeated stimulation of neurons is the basis for learning and memory.
B) tetanic stimulation of the presynaptic neuron can produce LTP in the recipient cell.
C) overexposure to excitatory amino acid transmitters can result in depolarization and cell death.
D) glutamate and aspartate play a critical role in the action of drugs like PCP.

Question

Quizplus · Accepted Answer

The excitotoxicity hypothesis suggests that overexposure to excitatory amino acid transmitters (such as glutamate) can lead to excessive depolarization of neurons, ultimately causing cell death. This is due to the overactivation of receptors, leading to calcium influx and activation of destructive cellular pathways.

The Excitotoxicity Hypothesis States That