Dopamine transporter knockout mice are hyperactive relative to wild-type mice because
A) they produce more dopamine than wild-type mice.
B) they have fewer receptors than wild-type mice.
C) their dopaminergic neurons cannot remove dopamine from the synaptic cleft.
D) they cannot synthesize dopamine.

Question

Quizplus · Accepted Answer

Dopamine transporter knockout mice are hyperactive because the dopamine transporter, which normally removes dopamine from the synaptic cleft and terminates its action, is not functional. This leads to increased dopamine activity.

Dopamine Transporter Knockout Mice Are Hyperactive Relative to Wild-Type Mice