In ketone body biosynthesis,the HMG-CoA lyase reaction is mechanistically the reverse of the first half of the reaction catalyzed by a particular TCA enzyme.Which of the following TCA enzymes does it resemble?

Question

Quizplus · Accepted Answer

The HMG-CoA lyase reaction is mechanistically similar to the first half of the reaction catalyzed by citrate synthase, as both reactions involve the cleavage of a thioester bond in a similar manner. Aconitase and malate dehydrogenase catalyze different reactions in the TCA cycle, and succinyl-CoA synthase catalyzes a reaction that involves a phosphorylation rather than a cleavage.

In Ketone Body Biosynthesis,the HMG-CoA Lyase Reaction Is Mechanistically the Reverse