Which of the following enzymes catalyzes this reaction?
Base + PRPP → nucleoside-5-phosphate + PPᵢ
A)nucleotide diphosphate kinase
B)phosphoribosyltransferase
C)ribose-5-phosphate pyrophosphokinase
D)adenylate kinase

Question

Quizplus · Accepted Answer

Phosphoribosyltransferase catalyzes the reaction of adding a ribose phosphate group to a base, with PRPP as the sugar phosphate donor, to form nucleoside-5-phosphate. This is a key step in nucleotide biosynthesis. The resulting PPi is cleaved by pyrophosphatase to release two inorganic phosphates. Nucleotide diphosphate kinase catalyzes the transfer of a phosphate group from a nucleoside diphosphate to ATP to form a nucleoside triphosphate, while ribose-5-phosphate pyrophosphokinase catalyzes the synthesis of PRPP from ribose-5-phosphate and ATP. Adenylate kinase catalyzes the transfer of a phosphate group between ADP and ATP.

Which of the Following Enzymes Catalyzes This Reaction