Which inhibitor of protein synthesis competes with aminoacyl-tRNAs for binding to the A-site of the ribosome?

Question

Quizplus · Accepted Answer

Puromycin is a structurally similar analog of aminoacyl-tRNA that binds to the A-site of the ribosome and causes premature termination of protein synthesis. This competition for binding to the A-site inhibits the elongation of the peptide chain, leading to the inhibition of protein synthesis. Erythromycin binds to the peptidyl transferase center, cycloheximide binds to the 60S ribosomal subunit, and tetracycline inhibits the binding of aminoacyl-tRNA to the A-site.

Which Inhibitor of Protein Synthesis Competes with Aminoacyl-TRNAs for Binding