Which of the following pathophysiological changes potentially noted in patients with CHF results in the heart becoming insensitive to beta-adrenergic stimulation?

Question

Quizplus · Accepted Answer

The insensitivity to beta-adrenergic stimulation is the result of a decrease in beta₁-adrenergic receptor density and is very important because the heart normally contains a ratio of 3.3 to 1.0 beta₁- to beta₂-adrenergic receptors.In CHF the ratio drops to 1.5 to 1.0 producing a 62% decrease in beta₁-adrenergic receptors.

Which of the Following Pathophysiological Changes Potentially Noted in Patients