Which of the following reasons BEST supports the administration of vascular endothelial growth factor (VEGF)with a collagen-binding domain (CBD),an agent that is used for stimulating the growth of new blood vessels?

Question

Quizplus · Accepted Answer

The adult heart has been shown to have a reduced ability to produce growth factors and stimulate angiogenesis in response to ischemia.VEGF has several isoforms and is considered to be a potent angiogenic agent because it is endothelial cell specific.The delivery system should target the injured myocardium to improve the local therapeutic efficacy of VEGF and decrease its possible adverse effects.Use of a collagen-binding domain with VEGF aids the VEGF to be retained in the cardiac extracellular matrix,which is rich in collagen I.

Which of the Following Reasons BEST Supports the Administration of Vascular