Use of nonselective beta-blockers may be MOST detrimental to which of the following special patient populations during physical activity?

Question

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Caution should be taken with patients who have COPD and who are taking beta-blocking medications,specifically nonselective beta-blockers.These medications block sympathetic stimulation to the beta₁ receptors in the heart as well as the beta₂ receptors found in the smooth muscles of the bronchi.The result of blocked beta₂ receptors can be bronchoconstriction resulting in an increase in dyspnea.

Use of Nonselective Beta-Blockers May Be MOST Detrimental to Which