The Nurse Is Reviewing a Client's Medication and Learns That

The nurse is reviewing a client's medication and learns that the client has been taking prednisone. What is the nurse's understanding of the effect of prednisone on the adrenal glands?

A) Prednisone therapy results in destruction of the adrenal medulla, thereby decreasing corticotropin releasing hormone.
B) Prednisone therapy can lead to significant toxicity, resulting in dehydration, fever, and hyponatremia.
C) Prednisone therapy increases cortisol and decreases adrenocorticotropic hormone via negative feedback principles.
D) Prednisone therapy increases sodium and water resorption and potassium and hydrogen excretion.