The three chromosomal abnormalities that cause Down's Syndrome are:

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Down's Syndrome is caused by the presence of an extra copy of chromosome 21, known as trisomy 21, in all or some of the body's cells. In some cases, Down's Syndrome can also be caused by a translocation of a portion of chromosome 21 onto another chromosome. This occurs in about 4% of cases. Additionally, individuals with Down's Syndrome may exhibit mosaicism, where some cells in the body have an extra copy of chromosome 21, while others do not.

The Three Chromosomal Abnormalities That Cause Down's Syndrome Are