All of the Following Statements Related to the Binding of Drugs

All of the following statements related to the binding of drugs by plasma proteins are correct EXCEPT?

A) Bound drug is unable to diffuse into tissue until it becomes unbound.
B) A drug that is bound by plasma proteins will have a smaller apparent volume of distribution than if it were not bound.
C) Displacement of the bound drug by another drug can increase the effects of a given dosage of the first drug.
D) Acidic drugs are bound mostly to plasma albumin.
E) Bound drug is the pharmacologically active part of the drug