All of the following about free drugs (unbound drags) in plasma are correct EXCEPT:
A) Only free drugs can distribute to peripheral tissues
B) Only free drugs can pass through glomerular filtration
C) Only free drugs become available for hepatic metabolism
D) Highly bound drugs (98% bound) have clinically significant drug-drug interactions with other drugs through displacement from binding sites on plasma protein
E) Basic drugs bind with acidic binding sites on plasma globulins while acidic drugs bind with basic binding sites on plasma albumin
Correct Answer:
Verified
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