Disappearance of Most Drugs from the Plasma Follows First Order

Disappearance of most drugs from the plasma follows first order kinetics, which means that:

A) The rate of disappearance is independent of the amount of drug left at any time
B) The rate of disappearance is proportional to the amount of drug left at any time
C) The disposition mechanisms are saturated
D) The drug is rapidly metabolized
E) The rate of disappearance is proportional to clearance rate