Pharmacokinetic Characteristics of Propranolol Include Vd = 300 L/70 Kg

Pharmacokinetic characteristics of propranolol include Vd = 300 L/70 kg, CL = 700 mL/min, and oral bioavailability f = 0.25. What is the dose needed to achieve a plasma level equivalent to a steady-state level of 20 ?g/L?

A) 4 mg
B) 8 mg
C) 12 mg
D) 24 mg
E) 48 mg