A solution Verapamil is administered to the portal vein of the isolated perfused liver of a rat at a concentration of 8.9 mg/L. After 5 minutes, the concentration that is measured at the hepatic vein is 2.99 mg/L and the hepatic blood flow is 1050 mL/min. What is the hepatic extraction rate (ERH) of verapamil in this model/Hepatic clearance respectively

Question

Quizplus · Accepted Answer

The hepatic extraction ratio (ERH) is calculated using the formula: ERH = (Cin - Cout) / Cin, where Cin is the concentration entering the liver (8.9 mg/L) and Cout is the concentration leaving the liver (2.99 mg/L). ERH = (8.9 - 2.99) / 8.9 = 0.664. The hepatic clearance is calculated as ERH * hepatic blood flow = 0.664 * 1050 mL/min = 696.2 mL/min. However, the closest option is A with 0.5286/687.2 mL/min, indicating a possible error in the provided options or calculations.

A Solution Verapamil Is Administered to the Portal Vein of the Isolated