Researchers develop a novel glycopeptide antibiotic similar to vancomycin(Hydrophilic drug) that is bactericidal against many Gram-positive bacteria. From animal studies, they determine that the effective drug dosage is 5 mg/kg/day administered intravenously in divided doses. In a clinical trial, the antibiotic is administered to adult and neonatal patients with gram-positive infections. The drug is found to be effective in adults but not in neonates. During further analysis, plasma concentrations of the drug are measured in both groups, with the results shown in the image below: Compared to adults, which of the following neonatal factors is the most likely cause of the difference in drug effectiveness?

Question

Researchers develop a novel glycopeptide antibiotic similar to vancomycin(Hydrophilic drug) that is bactericidal against many Gram-positive bacteria. From animal studies, they determine that the effective drug dosage is 5 mg/kg/day administered intravenously in divided doses. In a clinical trial, the antibiotic is administered to adult and neonatal patients with gram-positive infections. The drug is found to be effective in adults but not in neonates. During further analysis, plasma concentrations of the drug are measured in both groups, with the results shown in the image below:  Compared to adults, which of the following neonatal factors is the most likely cause of the difference in drug effectiveness?

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The Answer of Researchers develop a novel glycopeptide antibiotic similar to vancomycin(Hydrophilic drug) that is bactericidal against many Gram-positive bacteria. From animal studies, they determine that the effective drug dosage is 5 mg/kg/day administered intravenously in divided doses. In a clinical trial, the antibiotic is administered to adult and neonatal patients with gram-positive infections. The drug is found to be effective in adults but not in neonates. During further analysis, plasma concentrations of the drug are measured in both groups, with the results shown in the image below:  Compared to adults, which of the following neonatal factors is the most likely cause of the difference in drug effectiveness?

Researchers Develop a Novel Glycopeptide Antibiotic Similar to Vancomycin(Hydrophilic Drug)