Genetic factors that influence immunogenicity include:
I- Decreased functional capacity of the immune system over time
II- Lack of a T cell clone with a TCR that reacts to the antigen
III- Defect in antigen processing and antigen presentation
A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Question

Quizplus · Accepted Answer

Lack of a T cell clone with a reactive TCR and a defect in antigen processing and presentation are both potential genetic defects that could influence immunogenicity. Age-related decrease in functional capacity of the immune system affects immunogenicity, but is caused by age and not genetics.

Genetic Factors That Influence Immunogenicity Include