The activation of inositol-1,4,5-triphosphate (IP₃) signaling results in:
A) Activation of NF-kB signaling
B) Release of intracellular calcium
C) Phosphorylation of downstream targets
D) Formation of the immunological synapse

Question

Quizplus · Accepted Answer

IP₃ signaling leads to release of intracellular calcium stores. This signaling process occurs for numerous reasons inside the cell, including muscle contraction and blood clotting. In the immune response, IP₃ signaling and release of intracellular calcium stores result in activation of NFAT. The released calcium binds to calmodulin, which activates calcineurin. Calcineurin activates NFAT, which is one of the transcription factors required for IL-2 synthesis.

The Activation of Inositol-1,4,5-Triphosphate (IP₃) Signaling Results In