Which region of the antibody is important for physical flexibility of the antigen binding region?

Question

Quizplus · Accepted Answer

The hinge region is the part of the CH2 region that contains a disulfide bond and allows the antibody the flexibility it needs to be able to bind to antigens of different sizes. The J chain is part of the IgM antibody and allows binding to the receptor that transports secretory IgM across epithelial cells, and also allows for attachment of the secretory piece that protects secretory IgM from enzymatic degradation. The variable regions of both light and heavy chains are the portions of the antibody that bind to antigen.

Which Region of the Antibody Is Important for Physical Flexibility