What is the mechanism of action of the sipuleucel-T prostate cancer vaccine?
A) Dendritic cells are incubated with a fusion protein containing prostate specific antigen (PSA) and GM-CSF.
B) A plasmid that codes for an antibody that expresses prostate specific antigen (PSA), and dendritic cells present PSA to T cells.
C) A single B cell clone that is tumor specific is grown in the lab and infused into the patient to produce large amounts of tumor specific antibody.
D) Patient tumor cells are exposed to a viral vector containing a gene for prostate specific antigen (PSA), and then the tumor cells are infused into the patient to stimulate an immune response.

Question

Quizplus · Accepted Answer

Patient dendritic cells are incubated with a fusion protein containing PSA and granulocyte-macrophage-colony stimulating factor (GM-CSF). The colony-stimulating factor will stimulate proliferation of dendritic cells, and the dendritic cells will present PSA antigens to T cells to stimulate an antitumor immune response.

What Is the Mechanism of Action of the Sipuleucel-T Prostate