Patients with tetanus experience characteristic unpredictable muscle spasms, which are caused by:

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The A subunit of tetanospasmin inactivates synaptobrevin, which prevents the release the GABA and glycine, which are inhibitory neurotransmitters. This lack of inhibition leads to uncontrolled release of acetylcholine, a neurotransmitter that stimulates muscle contractions under normal conditions but causes spasms during uncontrolled release. These continued spasms lead to spastic paralysis of the muscles involved.

Patients with Tetanus Experience Characteristic Unpredictable Muscle Spasms, Which Are