New variation in a species can occur only through

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New variation in a species can only occur through mutation, which is a permanent change in the DNA sequence. Natural selection can act on these new mutations, but it does not create them. Segregation and mitosis involve the distribution of existing genetic information, but they do not generate new genetic variation. Acquired inheritance, also known as Lamarckian inheritance, is not supported by scientific evidence and is not a mechanism for generating new genetic variation.

New Variation in a Species Can Occur Only Through