Which of the Following LEAST Supports the Idea of Genome

Which of the following LEAST supports the idea of genome reduction?

A) Pseudogenes found in some organisms are no longer expressed but have homology to functional genes in other species.
B) Virulence factors are found on pathogenicity islands.
C) Pathogenic shigellae lack major regions of genes that the closely related E. coli possesses.
D) Bacteria no longer need "pseudogenes" when growing in new environments.
E) Over half of the genome of the obligate intracellular pathogen, Mycobacterium leprae, is composed of pseudogenes that are no longer needed.