The gut is able to distinguish between indigenous microbiota and pathogens by using which part of epithelial cells?
A) TLRs and NLRs
B) SIgA
C) cytokines
D) IL-22
E) ILCs

Question

Quizplus · Accepted Answer

The gut is able to distinguish between indigenous microbiota and pathogens by using Toll-like receptors (TLRs) and NOD-like receptors (NLRs) on epithelial cells. These receptors recognize microbe-associated molecular patterns (MAMPs) that are present on both commensal and pathogenic microbes, but the response of the epithelial cells is different depending on the type of microbe. Pathogens typically induce a stronger response than commensal bacteria, leading to an inflammatory response that helps to eliminate the pathogen.

The Gut Is Able to Distinguish Between Indigenous Microbiota and Pathogens