In which of the following disorders does genomic imprinting operate on the sex chromosomes?

Question

Quizplus · Accepted Answer

Genomic imprinting is known to occur on the sex chromosomes in fragile X syndrome. In this disorder, the FMR1 gene on the X chromosome is silenced due to methylation of cytosine residues in the promoter region. This results in a reduction or absence of the FMR1 protein, which is important for the development and function of the nervous system. The imprinting pattern of the FMR1 gene is dependent on the parent of origin, with expansion of CGG repeats on the maternal allele causing the disease. The other disorders listed do not involve genomic imprinting on the sex chromosomes.

In Which of the Following Disorders Does Genomic Imprinting Operate