Part of the reason for the charge difference inside and outside a neuron's membrane is:

Question

Quizplus · Accepted Answer

Negatively charged proteins are found inside the neuron's membrane and contribute to the negative charge within the cell, as they cannot move out of the cell. Additionally, potassium ions are also abundant inside the neuron, contributing to the negative charge. Sodium ions are more abundant outside of the membrane, but they are positively charged and cannot account for the overall negative charge of the neuron. There may be some positively charged proteins outside the membrane but they would not contribute significantly to the overall charge difference.

Part of the Reason for the Charge Difference Inside and Outside