What Is the "Downside" to Extensive Use of Synthesized Nitrogen-Containing

What is the "downside" to extensive use of synthesized nitrogen-containing fertilizers?

A) The use of the fertilizers results in fertilizer resistance in crops.
B) The use of the fertilizers results in loss of a large percentage of crops to fertilizer burn every year
C) Nitrogen-rich runoff contributes to algal blooms and dead zones in bodies of water.
D) The expense of the process makes food less affordable.
E) Synthesized nitrogen interferes with transport in some plants.