Consider the HIV enzyme called protease.The amino acid residues at the active site are highly hydrophobic.In designing a drug that would bind to the active site and jam it,researchers should use which type of molecule?
A)hydrophobic
B)polar
C)charged
D)acidic

Question

Quizplus · Accepted Answer

Since the amino acid residues at the active site of HIV protease are highly hydrophobic, the drug molecule designed to bind to the active site and jam it should also be hydrophobic in nature. This is because hydrophobic molecules tend to interact favorably with other hydrophobic molecules, and hence a hydrophobic drug would be able to bind more tightly to the active site of the enzyme. Therefore, Option A is the best choice to design a drug that would bind to the active site and jam it.

Consider the HIV Enzyme Called Protease