Use the following information when answering the corresponding question(s).
Shu-ichi Nakano reported in Science in February 2000 that "the RNA enzyme (ribozyme) from hepatitis delta virus catalyzes self-cleavage of a . . . [chemical] . . . bond." This reaction is inherently slow due to the formation of an unfavorable negative charge on the ribozyme. The author goes on to show that this self-cleavage is made faster by joining it with an acid-base reaction that neutralizes the negative charge. Nakano's model describes a positively charged cytosine base on the ribozyme acting as the acid and magnesium hydroxide acting as the base. Specifically, the cytosine donates its proton (H+) to neutralize the unstable negative charge that would have formed on the ribozyme.
-Is Nakano's quote from Science consistent with the textbook's claim that RNA is a good candidate for the first life-form?
A) yes
B) no

Question

Quizplus · Accepted Answer

Nakano's report on RNA catalyzing self-cleavage and the importance of acid-base reactions in neutralizing negative charge supports the idea that RNA could have played a role in the origin of life. This is consistent with the textbook's claim that RNA is a good candidate for the first life-form. RNA's ability to carry genetic information and catalyze reactions makes it a plausible precursor to the more complex DNA-based life we see today.

Use the Following Information When Answering the Corresponding Question(s)