Canine phosphofructokinase (PFK)deficiency afflicts springer spaniels,affecting an estimated 10% of the breed.PFK is the glycolytic enzyme that phosphorylates fructose-1-phosphate and catalyzes the committed step in glycolysis.Given its critical role in glycolysis,one implication of the genetic defect resulting in PFK deficiency in dogs is _____.
A)early embryonic mortality
B)elevated blood-glucose levels in the dog's blood
C)an intolerance for exercise
D)a reduced life span

Question

Quizplus · Accepted Answer

The critical role of PFK in glycolysis means that dogs with PFK deficiency cannot produce enough ATP through glycolysis to maintain energy during exercise, resulting in exercise intolerance. Early embryonic mortality, elevated blood-glucose levels, and reduced life span are not directly related to PFK deficiency.

Canine Phosphofructokinase (PFK)deficiency Afflicts Springer Spaniels,affecting an Estimated 10% of the Breed.PFK