Which of the following contradicts the one-gene, one-enzyme hypothesis?
A) A mutation in a single gene can result in a defective protein.
B) Alkaptonuria results when individuals lack a single enzyme involved in the catalysis of homogentisic acid.
C) Sickle cell anemia results in defective hemoglobin.
D) A single antibody gene can code for different related proteins, depending on the splicing that takes place post-transcriptionally.

Question

Quizplus · Accepted Answer

The one-gene, one-enzyme hypothesis proposes that each gene codes for a single enzyme. However, in some cases, a single gene can produce multiple related proteins through alternative splicing, as in the case of antibodies. This contradicts the one-gene, one-enzyme hypothesis. Choices A, B, and C do not contradict the one-gene, one-enzyme hypothesis, as they all relate to the concept of a single gene encoding a single protein or enzyme.

Which of the Following Contradicts the One-Gene, One-Enzyme Hypothesis