When is a single base substitution mutation least likely to be deleterious?
A)when the single base change results in a stop codon
B)when the single base change results in a codon that specifies the same amino acid as the original codon
C)when the base change results in an amino acid substitution that alters the tertiary structure of the protein
D)when the base change results in an amino acid substitution at the active site of an enzyme

Question

Quizplus · Accepted Answer

When the single base change results in a codon that specifies the same amino acid as the original codon, it is referred to as a synonymous or silent mutation. These mutations do not result in changes to the protein sequence and are therefore least likely to be deleterious.

When Is a Single Base Substitution Mutation Least Likely to Be