Which of the following types of mutation would convert a proto-oncogene into an oncogene?
A) a mutation that blocks transcription of the proto-oncogene
B) a mutation that creates an unstable proto-oncogene mRNA
C) a mutation that greatly increases the amount of the proto-oncogene protein
D) a deletion of most of the proto-oncogene coding sequence

Question

Quizplus · Accepted Answer

A mutation that greatly increases the amount of the proto-oncogene protein can lead to its conversion into an oncogene. Proto-oncogenes normally promote cell growth and division, but when they are overexpressed due to mutation, they can become permanently activated and contribute to the uncontrolled cell growth seen in cancer. Blocking transcription or deleting the coding sequence would likely inactivate the proto-oncogene altogether, while creating an unstable mRNA would not necessarily increase protein levels.

Which of the Following Types of Mutation Would Convert a Proto-Oncogene