An antibody screen on a patient with a prior history of transfusion was negative. The crossmatch, performed at immediate spin and antihuman globulin, was incompatible with 1 unit selected. The next step in the investigation would be to:

Question

Quizplus · Accepted Answer

The most likely reason for the incompatibility is that the blood unit has a positive direct antiglobulin test or the patient has developed an antibody to a low-frequency antibody. If the direct antiglobulin test is negative, testing the patient's serum against a selected cell panel of low-frequency antigen positive cells should be performed.

An Antibody Screen on a Patient with a Prior History