Under what circumstances did Moscow become the dominant city in the Byzantine Orthodox world?

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Moscow became the dominant city in the Byzantine Orthodox world after Constantinople was overrun by Muslims in 1453, which led to the decline of its influence and power. Moscow, as a powerful principality, emerged as a new center of Orthodox Christianity and became the seat of the metropolitan bishop, playing a significant role in the religious and political affairs of the Orthodox world.

Under What Circumstances Did Moscow Become the Dominant City in the Byzantine