Optimal recovery of filamentous fungi from blood specimens requires

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Those laboratories that have a high incidence of dimorphic fungi recovered from blood are encouraged to use the lysis-centrifugation system, which has been shown to be optimal for the recovery of H. capsulatum and other filamentous fungi. With this system, blood cells that may contain the microorganisms are lysed, and centrifugation concentrates the organisms before culturing. The concentrate is inoculated onto the surface of appropriate culture media, and most fungi are detected within the first 4 days of incubation.

Optimal Recovery of Filamentous Fungi from Blood Specimens Requires