The presence of nonbudding, thick-walled spherules containing granular material in a KOH preparation of cerebrospinal fluid usually indicates infection with

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Quizplus · Accepted Answer

In direct microscopic examinations of sputum or other body fluids, C. immitis appears as a nonbudding, thick-walled spherule, 20 to 200 μm in diameter, containing either granular material or numerous small (2 to 5 μm in diameter), nonbudding endospores. The endospores are freed by rupture of the spherule wall; therefore, empty and collapsed "ghost" spherules may also be present.

The Presence of Nonbudding, Thick-Walled Spherules Containing Granular Material in a KOH