The Most Reliable Specimen for Determining the Etiology of Ulcers

The most reliable specimen for determining the etiology of ulcers and nodules are

A) from the base of the ulcer or nodule.
B) those collected following removal of overlying debris.
C) those collected by surgical biopsy of deep tissues.
D) those collected without contact with the superficial layers of the lesion.
E) All of the above are correct.