The Economic Crisis in the Late Sixteenth Century Was Primarily

The economic crisis in the late sixteenth century was primarily due to​

A) ​collapse of the trading infrastructure within China.
B) ​attacks from subordinate territories in Vietnam.
C) ​Spanish piracy against Dutch shipping and trade.
D) ​interruption of the silver imports from the Americas.
E) ​a devastating plague that killed off nearly one-third of the taxpaying population.