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In Fragile X Syndrome, Only Noncoding Regions Within the Gene

Question 10

Multiple Choice
In fragile X syndrome, only noncoding regions within the gene for a protein that directs and maintains brain development are heavily methylated, resulting indecreasedcognitive ability and behavioral problems. What is the most likely mechanism of this abnormal expression?

In fragile X syndrome, only noncoding regions within the gene for a protein that directs and maintains brain development are heavily methylated, resulting indecreasedcognitive ability and behavioral problems. What is the most likely mechanism of this abnormal expression?


A) Increased microRNA molecules reducing the synthesis of the gene product
B) Failure of the methylated regions to undergo translation
C) Suppression of the "splicing out" action for introns
D) Suppression of promoter function

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