Which statement about partial deletions and duplications of autosomes is true?
A)If one child in a family has the abnormality, the risk for recurrence is 50% with each pregnancy.
B)The aberration represents failure of chromosomal segregation during gametogenesis.
C)The underlying cause is random chromosome breakage and rearrangement.
D)The incidence increases with advancing maternal or paternal age.

Question

Quizplus · Accepted Answer

Unlike trisomy and monosomy, most partial chromosome duplications and deletions are random events that result from chromosomal breakage and structural rearrangement, usually during gametogenesis. They are not related to parental age, and because many individuals who have the duplication or deletion are not capable of reproduction, and unless the source of the ovum or sperm involved is the unbalanced haploid gamete of a balanced translocation carrier, there is little risk for passing on the aberration.

Which Statement About Partial Deletions and Duplications of Autosomes Is