If a man with Gaucher type 1 has children with a woman who is a carrier for the disorder, what is the expected risk pattern?
A)All sons will be unaffected; all daughters will be carriers.
B)All sons will be carriers; all daughters will be affected.
C)All children will have one mutated allele and will at least be carriers; each child of either gender has a 50% risk of having the disease.
D)Each child of either gender has a 50% risk of being a carrier, a 25% risk of having the disease, and a 25% risk of neither being a carrier nor having the disease.

Question

Quizplus · Accepted Answer

The GBA gene, which is mutated in Gaucher type 1, is located on chromosome 1q21, and the disease is transmitted in an autosomal-recessive pattern. Therefore, there is no gender difference in risk between sons and daughters.

If a Man with Gaucher Type 1 Has Children with a Woman