How are the two mucopolysaccharide disorders Hurler syndrome and Hunter syndrome different?
A)Hurler syndrome is an autosomal-dominant disorder, and Hunter syndrome is autosomal recessive.
B)Hunter syndrome is an autosomal-dominant disorder, and Hurler syndrome is autosomal recessive.
C)Individuals with Hurler syndrome become cognitively impaired in early childhood, whereas those with Hunter syndrome often retain intellectual ability until later in life.
D)Individuals with Hunter syndrome become cognitively impaired in early childhood, whereas those with Hurler syndrome often retain intellectual ability until later in life.

Question

Quizplus · Accepted Answer

The actual pathophysiology of Hunter syndrome with regard to poor degradation of mucopolysaccharides is identical to that of Hurler syndrome. Major differences are that people with Hunter syndrome have a slower onset of symptoms, and the effect on intellectual ability is more variable. In mild forms, loss of intellectual ability is minimal. In more severe forms, the loss of intellectual ability is more severe but occurs much later than in Hurler syndrome. Hurler syndrome is an autosomal-recessive disorder resulting in deficient function of the enzyme alpha-L iduronidase, and Hunter syndrome is an X-linked recessive disorder with deficient function of the enzyme iduronate sulfatase.

How Are the Two Mucopolysaccharide Disorders Hurler Syndrome and Hunter