Which result of genetic/genomic variation has the most support as a cause of asthma?

Question

Quizplus · Accepted Answer

Common areas of identified genomic variation associated with atopic asthma include those areas that contain genes coding for proteins that are important in regulating inflammatory reactions and immune responses. One of the strongest associations currently identified with susceptibility to asthma involves 8 to 12 different single-nucleotide polymorphisms at the 1q31 locus, encoding the gene DENND1B, which produces a protein strongly active in the work of two dendritic-type cells of the immune system, the macrophage and the mast cell. Both of these cell types are involved in nonspecific inflammatory responses and in acquired (adaptive) immune responses that develop individually in susceptible people when they are exposed to an allergen.

Which Result of Genetic/genomic Variation Has the Most Support as a Cause