Your patient's family comes from Ireland. Both her parents are carriers of gene mutations causing hereditary hemochromatosis (HFE-HHC). What is your patient'srisk of having the clinical signs of this disorder?

Question

Quizplus · Accepted Answer

Although the disorder is autosomal recessive, which should confer a 25% risk when both parents are carriers, it demonstrates incomplete penetrance, which is normally an issue seen with traits that have an autosomal-dominant inheritance pattern. As a result, the risk for this patient actually expressing the disorder and having clinical symptoms cannot be predicted accurately.

Your Patient's Family Comes from Ireland