Why is factor V Leiden disorder considered a form of thrombophilia?
A)Platelet activity is impaired.
B)Blood clots form more easily.
C)Atherosclerosis development is accelerated.
D)Excessive bleeding episodes occur in response to minor trauma.

Question

Quizplus · Accepted Answer

Proteins of the coagulation cascade are supposed to be degraded by activated protein C (APC) so that they do not become too large or stay around too long. In people with factor V Leiden disorder, F5 (the factor V Leiden protein) is abnormal and cannot be degraded. Thus, the person experiences a state of "hypercoagulation." It is not related to platelet aggregation and results in blood clots rather than bleeding. It is a single-gene problem unrelated to atherosclerosis.

Why Is Factor V Leiden Disorder Considered a Form of Thrombophilia