Which condition or factor improves the initial bioavailability of a drug agonist that has extensive first-pass loss as a result of the patient's enhanced liver enzymeactivity?
A)Increasing the patient's fluid intake
B)Co-administering the drug with an antagonist
C)Administering the drug by the intravenous route
D)Crushing the oral form of the drug before administration

Question

Quizplus · Accepted Answer

Bioavailability is the percentage of drug present in the bloodstream. When a drug is administered intravenously, it is all (100%) bioavailable initially. Increasing fluid intake does not affect bioavailability regardless of whether the fluid is taken orally or administered intravenously. Administering an antagonist along with a drug agonist would only cancel out or negate the agonist action, not improve the bioavailability. Crushing an oral drug does not prevent first-pass loss or improve bioavailability.

Which Condition or Factor Improves the Initial Bioavailability of a Drug